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Ultrasound Contrast Agent Modeling: A Review
Michel Versluis1, Eleanor Stride2, Guillaume Lajoinie1
1Physics of Fluids Group, MESA+ Institute for Nanotechnology, Technical Medical (TechMed) Center, University of Twente, Enschede, the Netherlands.
Ultrasound in Medicine & Biology
|June 18, 2020
Summary
This review covers theoretical models for ultrasound contrast agents (UCAs), which are microscopic bubbles used in medical imaging. Understanding UCA behavior is key to developing advanced diagnostic tools.
Area of Science:
- Medical Imaging
- Acoustics
- Biomedical Engineering
Background:
- Ultrasound is a safe, real-time medical imaging modality.
- Ultrasound contrast agents (UCAs) enhance ultrasound imaging via microbubbles.
- Research is ongoing to understand UCA physical properties and interactions.
Purpose of the Study:
- To review theoretical models for predicting UCA behavior.
- To cover UCA development and fundamental bubble dynamics.
- To explore advanced models for UCA-ultrasound interactions.
Main Methods:
- Review of existing theoretical models for UCA dynamics.
- Analysis of linear and non-linear models for shell properties.
- Inclusion of models for non-spherical oscillations and higher-order effects.
Main Results:
- Comprehensive overview of UCA theoretical modeling.
- Discussion of models incorporating shell elasticity and viscosity.
- Consideration of factors like surrounding tissue and acoustic forces.
Conclusions:
- Theoretical models are crucial for UCA characterization.
- Advanced models are needed for complex UCA behaviors.
- Future directions include novel UCA development and modeling.
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