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Analysis of Congenital Heart Defects in Mouse Embryos Using Qualitative and Quantitative Histological Methods
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Ventricular and total brain volumes in infants with congenital heart disease: a longitudinal study

Cynthia Hayek1,2, V Rajagopalan3, J Meouchy4

  • 1USC Division of Neonatal Medicine of the LAC+USC Medical Center, University of Southern California, Los Angeles, CA, USA. cynthiahayek0@gmail.com.

Journal of Perinatology : Official Journal of the California Perinatal Association
|June 18, 2020
PubMed

Insights

Quantitative MRI reveals brain changes in fetuses with congenital heart disease (CHD). Ventricular volumes decreased post-surgery, while total brain volumes increased, suggesting improved blood flow.

Area of Science:

  • Neuroimaging
  • Pediatric Cardiology
  • Developmental Biology

Background:

  • Quantitative MRI identifies delayed brain development in fetuses with congenital heart disease (CHD).
  • Ventriculomegaly serves as an early indicator of fetal brain dysmaturity.

Purpose of the Study:

  • To longitudinally evaluate cerebral ventricular and total brain volumes (TBV) in infants with CHD compared to normal neonates.
  • To assess fetal brain dysmaturity and its progression postoperatively.

Main Methods:

  • Fetal and post-operative MRIs were acquired from fetuses/neonates with CHD requiring intervention within the first month of life.
  • Volumetric measurements were performed using ITK-SNAP and analyzed post-hoc.

Main Results:

  • A significant decrease in ventricular volumes was observed from the fetal to the postoperative neonatal period (p=0.0297).
  • Infants with hypoplastic left heart syndrome (HLHS) showed a significant postoperative increase in TBV (p=0.0396).

Conclusions:

  • Postoperative increases in TBV were inversely correlated with decreasing ventricular volumes.
  • This phenomenon may be attributed to increased brain blood flow following surgical intervention.
Abstract

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