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Askin Gülsen1, Bettina Wedi2, Uta Jappe3

  • 1Division of Clinical and Molecular Allergology, Research Center Borstel, Borstel, Germany.

Allergo Journal : Interdisziplinare Zeitschrift Fur Allergologie Und Umweltmedizin : Organ Der Deutschen Gesellschaft Fur Allergie- Und Immunitatsforschung
|June 18, 2020
PubMed
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Biotechnological substances (BSs) can cause hypersensitivity reactions (HSRs), ranging from mild to severe anaphylaxis. A standardized classification system is needed to improve awareness and management of these complex immune-derived adverse events.

Area of Science:

  • Immunology
  • Pharmacology
  • Allergology

Context:

  • Biotechnological substances (BSs) are crucial in treating various diseases, including cancer and inflammatory conditions.
  • These biologics can elicit immune responses, leading to hypersensitivity reactions (HSRs).
  • HSRs range in severity and can be challenging to differentiate due to overlapping symptoms.

Purpose:

  • To review and analyze hypersensitivity reactions (HSRs) associated with biotechnological substances (BSs).
  • To highlight the diagnostic challenges in differentiating various HSRs, including anaphylaxis.
  • To emphasize the need for a standardized classification system for HSRs to BSs.

Summary:

  • Biotechnological substances (BSs) can cause a spectrum of hypersensitivity reactions (HSRs), often presenting with overlapping symptoms.

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  • Current literature lacks clear differentiation between various HSRs, with many severe reactions misclassified as anaphylaxis.
  • A simplified, symptom-based classification system is urgently required for better HSR awareness and management.

    • Impact:

    • Improved understanding and classification of HSRs to BSs will enhance patient safety.
    • Standardized HSR management protocols can lead to safer immunotherapy with BSs.
    • This research aims to facilitate timely control of unexpected adverse reactions, improving clinical outcomes.