Related Experiment Video
Updated: Dec 18, 2025

Multidisciplinary Approach to Obesity Management: A Case Report
Published on: May 30, 2025
A 3-Week Multidisciplinary Body Weight Reduction Program Improves Body Composition and Lower Limb Power Output in
Stefano Lazzer1,2,3, Giulia Bravo1, Gabriella Tringali3
1Department of Medicine, University of Udine, Udine, Italy.
Insights
A 3-week body weight reduction program significantly reduced fat mass and maintained fat-free mass in obese children and adolescents. This program also enhanced lower limb muscle power (LLP) output, improving physical function in young individuals.
Area of Science:
- Pediatric Obesity Research
- Sports Medicine and Physiology
- Body Composition Analysis
Background:
- Childhood obesity is a growing global health concern.
- Obesity negatively impacts body composition and physical function in children and adolescents.
- Effective interventions are needed to manage pediatric obesity and its consequences.
Purpose of the Study:
- To evaluate the impact of a 3-week in-hospital body weight reduction program (BWRP) on body composition and lower limb muscle power (LLP) in obese youth.
- To assess changes in fat mass (FM), fat-free mass (FFM), and LLP before and after the intervention.
- To determine the effectiveness of a comprehensive BWRP including diet, exercise, and psychological support.
Main Methods:
- A cohort of 3,778 obese children and adolescents (aged 8-18 years) participated in a 3-week BWRP.
- Body composition was measured using an impedancemeter at baseline (T0) and day 21 (T21).
- Lower limb muscle power (LLP) was assessed using the Margaria stair climbing test.
Main Results:
- Significant reductions in body mass (BM) and fat mass (FM) were observed in both girls and boys (p < 0.001).
- Fat-free mass (FFM) remained stable in both genders.
- Lower limb muscle power (LLP) significantly increased in absolute values and when normalized to BM and FFM in both genders (p < 0.001).
Conclusions:
- A 3-week BWRP effectively reduces fat mass while preserving lean body mass in obese children and adolescents.
- The program significantly improves lower limb muscle power, indicating enhanced physical capacity.
- These findings support the implementation of structured weight reduction programs for improving the health and physical function of obese youth.
Abstract:
The aim of the present study was to investigate the effects of a 3-week in-hospital body weight reduction program (BWRP), entailing moderate energy restriction, physical activity, psychological counseling and nutritional education, on body composition and lower limb muscle power (LLP) output in obese children and adolescents. Three thousand seven hundred seventy-eight obese [BMI: 36.2 ± 5.9 kg⋅m-2; fat mass (FM): 42.7 ± 4.0%] children and adolescents (2,318 girls and 1,460 boys, aged 8-18 year) participated in this study. Before (T0) and after the end of the BWRP (21st day, T21), body composition was assessed by an impedancemeter and LLP by the Margaria stair climbing test. Body mass (BM) and FM significantly decreased in girls (-4.8 and -7.1%, p < 0.001) and in boys (-5.5 and -9.3%, p < 0.001) after 3-week BWRP, while fat-free mass (FFM) did not change significantly in both genders. LLP expressed in absolute values (W) significantly increased in girls (by mean 6.4% from age 13 to 18 year, P < 0.001) and in boys (by mean 7.2% from age 12 to 18 year, P < 0.001). LLP normalized to BM (W⋅kg-1BM) significantly increased in girls (by mean 11.3%, P < 0.001) and boys (by mean 12.6%, P < 0.001) from age 9 to 18 year. As well, LLP normalized to FFM (W⋅kg-1FFM) significantly increased in girls (by mean 9.1% from age 9 to 18 year, P < 0.001) and in boys (by mean 10.1% from age 10 to 18 year, P < 0.001). In conclusion, 3-week BWRP induces a significant decrease in FM and maintenance in FFM in obese children and adolescents, these effects being also associated with a significant increase of LLP both in absolute terms and when normalized to the BM or FFM.
Related Concept Videos
Obesity
Drug Dosing: Obese Patients
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

