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Related Experiment Video

Updated: Dec 18, 2025

Surgical Treatment of an Endolymphatic Sac Tumor
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Intracranial Ewing Sarcoma - A case report.

Jiahua Huang1, Finn Ghent1, Robyn Levingston1

  • 1Department of Neurosurgery, St. George Public Hospital, Kogarah, New South Wales, Australia.

Surgical Neurology International
|June 18, 2020
PubMed
Summary
This summary is machine-generated.

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Intracranial Ewing sarcoma (ES) is a rare brain tumor. Surgical resection combined with chemotherapy and radiation is the recommended treatment for this aggressive central nervous system malignancy.

Area of Science:

  • Neuro-oncology
  • Pediatric oncology
  • Surgical oncology

Background:

  • Intracranial Ewing sarcoma (ES) is a rare neuroectodermal tumor, often presenting similarly to peripheral primitive neuroectodermal tumors (pPNET).
  • Limited reported cases and lack of established treatment protocols highlight the need for further research.
  • Current management strategies involve surgery, with or without adjuvant chemotherapy and radiation.

Observation:

  • A 19-year-old patient presented with behavioral changes, initially showing unclear diagnosis on MRI and CT.
  • MRI with contrast revealed a large, extra-axial, heterogeneously enhancing left frontal mass.
  • The patient underwent gross total resection followed by adjuvant chemotherapy and radiation.

Findings:

  • The patient experienced no local or systemic recurrence at 12 months postoperatively.
Keywords:
Ewing’s sarcomaMeningeal tumorNeuro-oncologyPeripheral primitive neuroectodermal tumorSoft-tissue tumor

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  • Intracranial ES/pPNET exhibits nonspecific clinical and radiological features, indicating its locally invasive nature.
  • Distinguishing pPNET from cPNET is crucial for accurate prognosis and therapeutic decisions.

    • Implications:

    • This case underscores the importance of multimodal treatment including surgery, chemotherapy, and radiation for intracranial ES/pPNET.
    • Further studies are needed to establish standardized treatment protocols for this rare malignancy.
    • Accurate diagnosis and classification are vital for optimizing patient outcomes.