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Updated: Dec 18, 2025

Study of Protein-protein Interactions in Autophagy Research
Published on: September 9, 2017
Endoplasmic Reticulum Membrane and Contact Site Dynamics in Autophagy Regulation and Stress Response
1Cell Biology Department, Institut Necker-Enfants Malades (INEM), INSERM U1151-CNRS UMR 8253, Université de Paris, Paris, France.
Abstract:
Autophagy mobilizes a variety of intracellular endomembranes to ensure a proper stress response and the maintenance of cellular homeostasis. While the process of de novo biogenesis of pre-autophagic structures is not yet fully characterized, the role of the endoplasmic reticulum (ER) appears to be crucial in early steps of autophagic process. Here, I review and discuss various aspects of ER and ER-driven membrane contact site requirements and effects on mammalian organelles and endomembrane biogenesis, in particular during the early steps of autophagy-related membrane dynamics.
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