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Clinical Trial Design and Development Work Group Within the Quantitative Imaging Network.

Ella F Jones1, John M Buatti2, Hui-Kuo Shu3

  • 1School of Medicine, University of California San Francisco, San Francisco, CA.

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Summary

The Quantitative Imaging Network

Keywords:
Clinical Trial Design and Development (CTDD)Quantitative Imaging Network (QIN)

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Area of Science:

  • Oncology
  • Medical Imaging
  • Clinical Trials

Background:

  • The Quantitative Imaging Network's Clinical Trial Design and Development Working Group supports quantitative imaging (QI) in cancer clinical trials.
  • Over the past decade, the group has addressed challenges and opportunities in QI and radiation oncology clinical trials.

Purpose of the Study:

  • To outline the progress and activities of the Clinical Trial Design and Development Working Group.
  • To highlight efforts in standardizing QI reporting and validating QI tools.
  • To emphasize the importance of clinical user engagement for QI tool translation.

Main Methods:

  • Developing guidelines for standardized reporting of quantitative imaging.
  • Conducting a multireader study to validate positron emission tomography quantification software.
  • Engaging in outreach to cooperative groups and organizations to promote QI tool use.

Main Results:

  • Established guidelines for quantitative imaging reporting.
  • Validated a semi-automated positron emission tomography quantification software through a multireader study.
  • Fostered dialogue and collaboration with clinical users and external organizations.

Conclusions:

  • The Working Group has made significant contributions to the development, validation, and harmonization of QI methods for cancer clinical trials.
  • Standardized reporting and validated tools are crucial for the clinical translation of QI.
  • Ongoing collaboration with clinical users and organizations is essential for advancing QI in clinical decision-making.