Related Experiment Video
Updated: Dec 18, 2025
05:53
Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
10.5K
IGF-1 and cardiometabolic diseases: a Mendelian randomisation study
Susanna C Larsson1,2, Karl Michaëlsson3, Stephen Burgess4,5
1Department of Surgical Sciences, Uppsala University, Epihubben, 75185, Uppsala, Sweden. susanna.larsson@surgsci.uu.se.
Diabetologia
|June 18, 2020
Summary
Elevated Insulin-like Growth Factor 1 (IGF-1) levels increase the risk of type 2 diabetes and coronary artery disease. This study suggests a potential causal link between higher IGF-1 and type 2 diabetes risk.
Area of Science:
- Endocrinology
- Cardiovascular Science
- Metabolic Disease Research
Background:
- Abnormal serum Insulin-like Growth Factor 1 (IGF-1) levels are linked to type 2 diabetes and cardiovascular disease.
- The role of IGF-1 within the normal range in cardiometabolic diseases remains unclear.
Purpose of the Study:
- To investigate the causal associations between genetically predicted serum IGF-1 levels and cardiometabolic diseases using Mendelian randomization.
- To clarify the role of IGF-1 in the development of type 2 diabetes and related cardiovascular conditions.
Main Methods:
- Utilized Mendelian randomization with 416 single nucleotide polymorphisms (SNPs) associated with IGF-1 levels in 358,072 UK Biobank participants.
- Obtained genetic association estimates for type 2 diabetes, coronary artery disease, heart failure, atrial fibrillation, and ischemic stroke from large consortia.
Main Results:
- A genetic predisposition to elevated serum IGF-1 was associated with an increased risk of type 2 diabetes (OR 1.14, 95% CI 1.05-1.24) and coronary artery disease (OR 1.09, 95% CI 1.02-1.16).
- The association with coronary artery disease was partially mediated by type 2 diabetes.
- Limited evidence supported associations between IGF-1 and heart failure, atrial fibrillation, or ischemic stroke.
Conclusions:
- Increased serum IGF-1 levels may be causally associated with a higher risk of type 2 diabetes.
- The findings highlight the potential role of IGF-1 in the pathogenesis of type 2 diabetes.
Related Concept Videos
01:11Genome-wide Association Studies-GWAS
15.1K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
15.1K
01:30Coronary Artery Disease I: Introduction
773
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
773