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Clinical trial patient recruitment and retention practices improved globally between 2012 and 2019. More studies met enrollment goals, but site activation and enrollment rates varied internationally.

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Area of Science:

  • Clinical research operations
  • Biopharmaceutical industry
  • Global health studies

Background:

  • Patient recruitment and retention are critical challenges in clinical trial execution.
  • Previous research highlighted persistent difficulties in meeting enrollment targets.
  • Benchmarking current practices against historical data is essential for progress.

Purpose of the Study:

  • To benchmark patient recruitment and retention practices in global clinical trials.
  • To compare current data with findings from a study conducted 7 years prior.
  • To identify trends and variations in enrollment and retention strategies.

Main Methods:

  • Data collection focused on patient and site enrollment metrics.
  • Analysis included recruitment and retention tactics employed in clinical trials.
  • Comparative analysis was performed between data from 2012 and 2019.

Main Results:

  • A higher proportion of studies met or exceeded planned enrollment in 2019 compared to previous research.
  • Significant global differences were observed in site activation rates.
  • Variations in target to actual enrollment rates were noted across different regions.

Conclusions:

  • Clinical trial enrollment performance has shown improvement.
  • Global disparities in site activation and enrollment rates persist.
  • Further research is recommended to evaluate the effectiveness of specific recruitment and retention tactics worldwide.