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Besnoitia besnoiti-driven endothelial host cell cycle alteration

Zahady D Velásquez1, Sara Lopez-Osorio2,3, Learta Pervizaj-Oruqaj4,5,6

  • 1Institute of Parasitology, Biomedical Research Center Seltersberg, Justus Liebig University, Schubertstr. 81, 35392, Giessen, Germany. zahady.velasquez@vetmed.uni-giessen.de.

Parasitology Research
|June 18, 2020
PubMed
Summary

Besnoitia besnoiti infection in cattle endothelial cells differs from Toxoplasma gondii, inducing cell cycle stasis at G1-to-S transition. This parasite-driven modulation involves cyclin E1 upregulation and enhanced chromosome condensation, unlike T. gondii’s G2/M arrest.

Keywords:
Apicomplexan parasitesBesnoitia besnoitiCell cycle arrestCoccidiaHistone H3 S10

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