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Related Experiment Videos

Infantile lobar hyperinflation: expectant treatment.

D C Shannon, I D Todres, F M Moylan

    Pediatrics
    |June 1, 1977
    PubMed
    Summary

    This study on lobar hyperinflation in infants found hypoxemia due to V/Q inequality, worsening with crying. Most infants showed normal lung function within a year, though some required surgery or succumbed to complications.

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    Area of Science:

    • Pediatric Pulmonology
    • Neonatal Physiology

    Background:

    • Lobar hyperinflation, a condition mimicking "emphysema" in infants, presents unique physiological challenges.
    • Understanding the natural history and defects is crucial for infant respiratory care.

    Purpose of the Study:

    • To evaluate physiological defects in infants with lobar hyperinflation.
    • To track the natural history of this condition in neonates.

    Main Methods:

    • Utilized arterial blood gases (ABGs) analysis.
    • Employed 133xenon technique for regional lung function assessment.
    • Monitored 16 infants diagnosed with lobar hyperinflation.

    Main Results:

    • Resting hypoxemia was attributed to ventilation-perfusion (V/Q) inequality.
    • Crying exacerbated hypoxemia through shunting in affected lobes.
    • Three infants required surgical intervention.
    • Two deaths occurred due to bronchopulmonary dysplasia post-respiratory distress syndrome (RDS).
    • 12 of 14 infants achieved normal lung function between 5 days and 1 year of age.

    Conclusions:

    • Lobar hyperinflation in infants is characterized by V/Q inequality and shunting.
    • While serious complications can occur, many infants demonstrate significant recovery of lung function.
    • Early assessment of blood gases and regional lung function aids in management.

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