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MicroRNAs in Sarcopenia: A Systematic Review

Katsunori Yanai1, Shohei Kaneko1, Hiroki Ishii1

  • 1Division of Nephrology, First Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University, Saitama, Japan.

Frontiers in Medicine
|June 18, 2020
PubMed

Insights

Sarcopenia, the loss of skeletal muscle, is linked to disability and mortality. This review explores how microRNAs (miRNAs) regulate sarcopenia development.

Area of Science:

  • Gerontology
  • Molecular Biology
  • Biochemistry

Background:

  • Sarcopenia, characterized by skeletal muscle loss, is a significant health concern linked to physical disability, illness, and mortality.
  • MicroRNAs (miRNAs) are key regulators of gene expression, influencing various biological processes.
  • Emerging evidence suggests miRNAs play critical roles in the pathogenesis of sarcopenia.

Conclusions:

  • MicroRNAs (miRNAs) are crucial regulators in the development and progression of sarcopenia.
  • Targeting specific miRNAs presents a potential therapeutic strategy for combating muscle loss.
  • Further research is needed to fully elucidate the intricate roles of miRNAs in sarcopenia.
Keywords:
microRNAmyoblastmyocytemyotubesarcopeniasystematic review

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