Related Experiment Video
Updated: Dec 18, 2025
09:21
Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas
Published on: September 13, 2019
7.5K
Primary Biatrial Cardiac Rhabdomyosarcoma
Tetsuro Uchida1, Yoshinori Kuroda1, Mitsuaki Sadahiro1
1Yamagata University Faculty of Medicine Second Department of Surgery Yamagata Japan Second Department of Surgery, Faculty of Medicine, Yamagata University, Yamagata, Japan.
Brazilian Journal of Cardiovascular Surgery
|June 18, 2020
Summary
Primary cardiac rhabdomyosarcoma, a rare heart cancer, can affect both atria. Surgical resection is recommended for diagnosis and symptom relief, even with a poor prognosis.
Area of Science:
- Cardiology
- Oncology
- Surgical Pathology
Background:
- Primary malignant neoplasms of the heart are exceptionally rare.
- Cardiac rhabdomyosarcoma represents the second most frequent primary cardiac sarcoma.
- Biatrial involvement by cardiac sarcoma is an extremely uncommon presentation.
Observation:
- A case report details a 49-year-old female patient with a large biatrial cardiac rhabdomyosarcoma.
- The patient underwent surgical resection of the tumor.
- Local recurrence was subsequently treated with salvage chemotherapy.
Findings:
- Surgical resection is crucial for definitive diagnosis and symptomatic management of cardiac rhabdomyosarcoma.
- Despite a generally dismal prognosis, early surgical intervention is advocated.
- This case highlights the challenges and management of extensive biatrial cardiac sarcoma.
Implications:
- The findings underscore the importance of considering surgical resection in managing rare cardiac tumors.
- Aggressive surgical approaches may improve outcomes for select patients with cardiac sarcomas.
- Further research into multimodal treatment strategies for cardiac rhabdomyosarcoma is warranted.
Related Concept Videos
01:29Cardiomyopathy IV: Restrictive Cardiomyopathy
337
Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
337
01:03Rous Sarcoma Virus (RSV) and Cancer
6.0K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
6.0K
01:25Cardiomyopathy I: Introduction and Classification
383
Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
383
01:20The Retinoblastoma Gene
4.6K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
4.6K
01:13Structure of Cardiac Muscles
16.3K
Cardiac muscle, or myocardium, is a specialized type of muscle found exclusively in the heart. Its unique structural and functional characteristics enable the heart to perform its vital role of pumping blood throughout the body continuously and rhythmically. The cardiac muscle cells, or cardiomyocytes, possess an endomysium and perimysium but do not have an epimysium.
Compared to skeletal muscles, cardiac muscle cells are small and mostly have a single nucleus. Additionally, they are usually...
Compared to skeletal muscles, cardiac muscle cells are small and mostly have a single nucleus. Additionally, they are usually...
16.3K
01:29Cardiomyopathy III: Hypertrophic Cardiomyopathy
263
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
263