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Ubiquilin Networking in Cancers.

Salinee Jantrapirom1, Luca Lo Piccolo2, Dumnoensun Pruksakorn2,3,4

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Ubiquilins (UBQLNs) are key proteins coordinating cellular degradation pathways. This review explores their diverse roles in human cancers, focusing on genetic variants, prognostic potential, and therapeutic strategies.

Keywords:
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Area of Science:

  • Molecular Biology
  • Cancer Research
  • Cellular Biology

Background:

  • Ubiquilins (UBQLNs), part of the UBL-UBA protein family, act as adaptors in proteasome and autophagy degradation pathways.
  • UBQLN substrates are diverse, influencing numerous cellular functions, including oncogene stability and DNA repair.
  • The role of UBQLNs in human cancers has been a long-standing research focus.

Purpose of the Study:

  • To review genetic variants of UBQLNs associated with common cancers.
  • To evaluate UBQLNs as potential prognostic markers in cancer.
  • To provide an overview of UBQLN networks relevant to cancer pathways.

Main Methods:

  • Literature review of genetic variants and cancer associations.
  • Analysis of UBQLN network involvement in cancer-related cellular processes.
  • Discussion of UBQLN-based therapeutic strategies.

Main Results:

  • Summary of UBQLN genetic variants linked to major cancer types.
  • Assessment of UBQLN reliability as a prognostic indicator.
  • Identification of UBQLN networks impacting cell cycle, apoptosis, EMT, DNA repair, and miRNAs in cancer.

Conclusions:

  • Ubiquilins play multifaceted roles in cancer development and progression.
  • UBQLN genetic variants and network interactions offer insights into cancer biology.
  • Targeting ubiquilins presents a promising avenue for novel cancer therapies.