Related Experiment Video

Updated: Dec 18, 2025

Profiling Ubiquitin and Ubiquitin-like Dependent Post-translational Modifications and Identification of Significant Alterations
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Profiling Ubiquitin and Ubiquitin-like Dependent Post-translational Modifications and Identification of Significant Alterations

Published on: November 7, 2019

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Ubiquilin Networking in Cancers

Salinee Jantrapirom1, Luca Lo Piccolo2, Dumnoensun Pruksakorn2,3,4

  • 1Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Muang, Chiang Mai 50200, Thailand.

Cancers
|June 19, 2020
PubMed

Insights

Ubiquilins (UBQLNs) are key proteins coordinating cellular degradation pathways. This review explores their diverse roles in human cancers, focusing on genetic variants, prognostic potential, and therapeutic strategies.

Area of Science:

  • Molecular Biology
  • Cancer Research
  • Cellular Biology

Background:

  • Ubiquilins (UBQLNs), part of the UBL-UBA protein family, act as adaptors in proteasome and autophagy degradation pathways.
  • UBQLN substrates are diverse, influencing numerous cellular functions, including oncogene stability and DNA repair.
  • The role of UBQLNs in human cancers has been a long-standing research focus.

Purpose of the Study:

  • To review genetic variants of UBQLNs associated with common cancers.
  • To evaluate UBQLNs as potential prognostic markers in cancer.
  • To provide an overview of UBQLN networks relevant to cancer pathways.

Main Methods:

  • Literature review of genetic variants and cancer associations.
  • Analysis of UBQLN network involvement in cancer-related cellular processes.
  • Discussion of UBQLN-based therapeutic strategies.

Main Results:

  • Summary of UBQLN genetic variants linked to major cancer types.
  • Assessment of UBQLN reliability as a prognostic indicator.
  • Identification of UBQLN networks impacting cell cycle, apoptosis, EMT, DNA repair, and miRNAs in cancer.

Conclusions:

  • Ubiquilins play multifaceted roles in cancer development and progression.
  • UBQLN genetic variants and network interactions offer insights into cancer biology.
  • Targeting ubiquilins presents a promising avenue for novel cancer therapies.
Keywords:
UBL-UBAautophagycancersgenetic variantsproteasomeubiquilins

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