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Development of an optical microfiber immunosensor for prostate specific antigen analysis using a

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    Optics Express
    |June 19, 2020
    PubMed
    Summary

    Researchers developed a novel fiber-optic biosensor using a high-order-diffraction long period grating (HOD-LPG) for detecting prostate specific antigen (PSA). This temperature-insensitive sensor shows promise for early PSA analysis.

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    Area of Science:

    • Biomedical Engineering
    • Optoelectronics
    • Chemical Sensing

    Background:

    • Fiber-optic biosensors are crucial for sensitive bio/chemical detection.
    • Prostate specific antigen (PSA) is a key biomarker for prostate cancer diagnosis.
    • Existing biosensors may face limitations in sensitivity, specificity, or environmental stability.

    Purpose of the Study:

    • To demonstrate a novel high-order-diffraction long period grating (HOD-LPG) biosensor.
    • To achieve temperature-insensitive and bending-independent detection of PSA.
    • To evaluate the sensor's performance for PSA quantification.

    Main Methods:

    • Fabrication of a HOD-LPG with specific grating parameters (period number < 10, elongated pitch).
    • Bio-functionalization of the HOD-LPG for PSA recognition.
    • Testing the sensor's response to varying concentrations of PSA in phosphate buffered saline.

    Main Results:

    • The HOD-LPG demonstrated temperature-insensitivity and bending-independence.
    • The biosensor successfully detected PSA in concentrations from 5 to 500 ng/ml.
    • An excellent specificity was observed, with a limit of detection of 9.9 ng/ml.

    Conclusions:

    • The developed HOD-LPG biosensor offers a promising platform for PSA detection.
    • The sensor's stability and sensitivity are suitable for clinical applications.
    • This technology could advance early diagnosis and monitoring of prostate cancer.