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Updated: Dec 18, 2025

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Published on: October 27, 2014
RNF8 induces β-catenin-mediated c-Myc expression and promotes colon cancer proliferation
Ling Ren1, Tingting Zhou2, Yang Wang3
1Department of Anorectal Surgery, the First Affiliated Hospital of China Medical University, Shenyang 110001, RP China.
Abstract:
DNA damage signals transducer RING finger protein 8 (RNF8) is involved in maintaining genomic stability by facilitating the repair of DNA double-strand breaks (DSB) via ubiquitin signaling. By analyzing the TCGA database and colon cancer tissue microarrays, we found that the expression level of RNF8 was positively correlated with that of c-Myc in colon cancer, which were closely associated with poor survival of colon cancer patients. Furthermore, overexpressing and knocking down RNF8 increased and decreased the expression of c-Myc in colon cancer cells, respectively. In addition, RNF8 interacted with β-catenin and facilitated its nuclear translocation by conjugating K63 polyubiquitination on it. These observations suggested a de novo role of RNF8 in promoting the progression of colon cancer by inducing β-catenin-mediated c-Myc expression.
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