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Published on: November 7, 2017
Uric acid and cardiometabolic diseases
Seung Jae Lee1, Byeong Kil Oh1, Ki-Chul Sung1
1Division of Cardiology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 29 Saemunan-ro, Jongno-gu, Seoul, 03181 Republic of Korea.
High uric acid (UA) levels are linked to serious health issues like heart disease and diabetes. Lowering UA may offer a new treatment strategy for these cardiometabolic conditions.
Area of Science:
- Cardiology
- Metabolic Diseases
- Nephrology
Background:
- Hyperuricemia is traditionally linked to gout and kidney stones.
- Emerging evidence suggests a connection between high uric acid and cardiometabolic diseases, including hypertension, heart failure, and insulin resistance.
Purpose of the Study:
- To review the association between uric acid and cardiometabolic diseases.
- To explore potential mechanisms linking uric acid to disease development.
- To discuss the therapeutic potential of uric acid-lowering strategies.
Main Methods:
- Review of clinical and experimental studies.
- Analysis of proposed mechanisms of action for uric acid.
- Evaluation of existing evidence for uric acid-lowering therapies.
Main Results:
- Uric acid (UA) is increasingly recognized as an independent risk factor for cardiometabolic diseases.
- Hypothesized mechanisms include oxidative stress, reduced nitric oxide bioavailability, inflammation, and endothelial dysfunction.
- Current evidence for UA-lowering therapy in cardiometabolic diseases is limited but promising.
Conclusions:
- Hyperuricemia is associated with a growing list of cardiometabolic conditions.
- Further large-scale clinical studies are needed to confirm the efficacy of UA-lowering treatments for these diseases.
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