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Epigenetic selection: an alternative mechanism of pattern formation
1Department of Botany, Hebrew University, Jerusalem, Israel.
Journal of Theoretical Biology
|October 21, 1988
Summary
Developmental biology may not rely on strict genetic programs. Instead, epigenetic selection from excess possibilities could guide pattern formation, allowing for variability and regeneration in developing organisms.
Area of Science:
- Developmental Biology
- Genetics
- Cell Biology
Background:
- Traditional models assume development follows pre-set genetic programs.
- Variability and regeneration suggest additional patterning mechanisms are at play.
Purpose of the Study:
- To propose a model of "epigenetic selection" for developmental pattern formation.
- To challenge the necessity of detailed genetic programs for development.
Main Methods:
- Conceptual modeling of developmental processes.
- Analysis of cell-cell competition and signal feedback loops.
- Hypothesizing mechanisms for spatial pattern generation.
Main Results:
- Developmental systems may select appropriate events from genetically equivalent possibilities.
- Pattern formation can emerge from competition for limited developmental signals.
- Facilitated transport of signals can lead to spatial patterning.
Conclusions:
- Epigenetic selection offers an alternative to rigid developmental programs.
- Cellular responses to signal availability, not just concentration, are crucial.
- This model redefines cellular traits and gene functions in patterned development.