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KCNQ1 common genetic variant and type 2 diabetes mellitus risk
Taraneh Erfani1, Negar Sarhangi2, Mahdi Afshari3
1Medical Genomics Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Background:
Type 2 diabetes mellitus (T2DM) is a multifactorial trait that both environmental and genetic factors contribute to its pathogenesis. The most common single nucleotide polymorphism (SNP) of the potassium voltage-gated channel subfamily Q member 1 (KCNQ1) gene, rs2237892, is highly associated with the risk of T2DM. The aim of the present study was to examine any association between KCNQ1 gene rs2237892 variant and risk of T2DM in a group of Iranian patients.
Methods:
Genotyping was carried out in 100 type 2 diabetic patients and 100 non-diabetic subjects using the Sanger sequencing method.
Results:
The CC genotype caused more than 30% reduction in the risk of T2DM in compared with CT. Nonetheless, this association was not statistically significant and this variant had no protective effect for T2DM. A significant difference was not found in genotypes (CC, CT, and TT) and alleles (C and T) frequency of KCNQ1 rs2237892 SNP between T2DM and control groups (P = 0.475 and P = 0.470, respectively).
Conclusions:
Our investigations did not show enough evidence for the presence of an association between KCNQ1 gene rs2237892 polymorphism and risk of T2DM among a group of Iranian patients.
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