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Helicobacter pylori infection and type 1 diabetes mellitus in children
Mohammad Reza Esmaeili Dooki1, Morteza Alijanpour Aghamaleki1,2, Negar Noushiravani3
1Non-Communicable Pediatric Diseases Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, IR Iran.
Insights
Helicobacter pylori infection was not significantly associated with type 1 diabetes in children aged 5-15. Glycemic control in children with type 1 diabetes was not affected by H. pylori infection.
Area of Science:
- Pediatric Endocrinology
- Infectious Diseases
- Gastroenterology
Background:
- Type 1 diabetes mellitus (T1DM) is an autoimmune disease affecting children globally.
- Helicobacter pylori (H. pylori) infection is a common gastrointestinal pathogen.
- The potential link between H. pylori and T1DM, and its impact on glycemic control, requires further investigation.
Purpose of the Study:
- To examine the association between H. pylori infection and T1DM in children.
- To assess the effect of H. pylori infection on glycemic control in children with T1DM.
Main Methods:
- A case-control study involving children with and without T1DM.
- Demographic data, gastrointestinal symptoms, diabetes duration, and glycemic control were recorded for T1DM patients.
- Stool antigen tests were performed to detect H. pylori infection in all participants.
Main Results:
- No significant difference in H. pylori infection rates was found between children with T1DM (27%) and controls (23.8%).
- Epigastric pain was more frequent in diabetic children with H. pylori (29.4%) compared to non-infected diabetic children (2.2%).
- No significant differences were observed in diabetes duration, age at diagnosis, fasting blood glucose, HbA1c, or insulin dosage between infected and non-infected T1DM patients.
Conclusions:
- H. pylori infection is not significantly associated with T1DM in children aged 5-15 years.
- H. pylori infection does not appear to impact glycemic control in children with T1DM.
Objectives:
This study aimed to investigate the association between Helicobacter pylori infection with diabetes mellitus type one and the effect of infected Helicobacter pylori on glycemic control.
Methods:
This case control study was conducted on children with and without type 1 diabetes mellitus (T1DM). Demographic data and gastrointestinal symptoms in both groups and glycemic control status and duration of diabetes were recorded in patients with T1DM. Stool test was done on all children to detect Helicobacter pylori antigen.
Results:
Sixty three children with T1DM with a mean of 10.88 ± 2.84 years and 105 control children with an average age 10.17 ± 2.55 years (P = 0/09) were involved in this study. The frequency of Helicobacter pylori infection in patients with T1DM was 17/63 (27%) and 25/105 (23.8%) in control group, (P = 0/64). The frequency of bloating, epigastric pain and nausea was not significantly different between the two groups. The frequency of epigastric pain in children with diabetes with helicobacter infection was significantly higher than non-infected children with diabetes (29.4% vs. 2.2%) (P = 0.004).The mean duration of diabetes (P = 0.53), age diagnosis of diabetes (P = 0.09), fasting blood glucose (P = 0.18), glycosylated hemoglobin (P = 0.08) and the daily insulin dose (P = 0.18) in patients with T1DM with and without helicobacter pylori infection had not significantly different.
Conclusions:
There was no significant association between Helicobacter pylori infection and diabetes in children 5-15 years old, and glycemic control status was not difference in patients with T1DM with and without Helicobacter pylori infection.
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