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The KNOW-CKD Study: What we have learned about chronic kidney diseases
Kook-Hwan Oh1, Minjung Kang1, Eunjeong Kang2
1Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
Kidney Research and Clinical Practice
|June 20, 2020
Summary
The KoreaN Cohort Study for Outcomes in Patients With Chronic Kidney Disease (KNOW-CKD) is Korea's largest CKD cohort, studying disease progression and outcomes. It aims to develop a prediction model for long-term consequences like end-stage renal disease.
Area of Science:
- Nephrology
- Epidemiology
- Clinical Research
Background:
- Chronic kidney disease (CKD) affects a significant population, necessitating comprehensive outcome studies.
- Understanding CKD progression and associated risks is crucial for patient management.
- The KoreaN Cohort Study for Outcomes in Patients With Chronic Kidney Disease (KNOW-CKD) represents a major national effort.
Purpose of the Study:
- To investigate the clinical course and risk factors for progression in adult CKD patients.
- To identify adverse outcomes associated with CKD, including cardiovascular disease and mortality.
- To establish a prediction model for long-term CKD consequences and facilitate early intervention.
Main Methods:
- Recruitment of 2,238 adult CKD patients (G1-G5) not on renal replacement therapy.
- Data collection from nine tertiary care hospitals across Korea between 2011 and 2016.
- Ongoing analysis of published research covering socio-economics, nutrition, quality of life, and clinical aspects.
Main Results:
- Over 50 articles published by 2019, covering diverse CKD-related research areas.
- Established a large, comprehensive cohort for studying CKD progression and outcomes.
- Identified key areas of investigation including cardiovascular comorbidity, anemia, and mineral bone disease.
Conclusions:
- The KNOW-CKD cohort is a valuable resource for advancing the understanding of chronic kidney disease.
- Future development of a prediction model will aid in identifying high-risk CKD populations.
- The study supports targeted interventions to improve long-term outcomes for CKD patients.
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