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Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
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Related Experiment Video

Updated: Dec 18, 2025

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
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12.4K

Emerging therapies in acute ischemic stroke.

Nicholas Liaw1, David Liebeskind1

  • 1Department of Vascular Neurology, University of California, Los Angeles, 635 Charles E Young Drive South, Suite 225, Los Angeles, California, 90095-7334, USA.

F1000Research
|June 20, 2020
PubMed
Summary

Acute ischemic stroke care is advancing with thrombolysis and mechanical thrombectomy. Collateral circulation, alongside time, is key for successful treatment, improving patient outcomes.

Keywords:
acute ischemic strokeartificial intelligencecollateralsmobile stroke unitneuroprotectionperfusionstent-retrieverstroketPAtelestrokethrombectomythrombolytics

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Area of Science:

  • Neurology
  • Cardiovascular Medicine
  • Emergency Medicine

Background:

  • Thrombolysis and mechanical thrombectomy have transformed acute ischemic stroke treatment.
  • Treatment decisions are increasingly influenced by factors beyond time since stroke onset, such as collateral circulation.

Purpose of the Study:

  • To review the advancements in acute ischemic stroke care.
  • To highlight the growing importance of collateral circulation in treatment selection.
  • To discuss the role of emerging technologies and systems of care in optimizing stroke treatment.

Main Methods:

  • Literature review of recent studies on acute ischemic stroke treatments.
  • Analysis of the impact of collateral circulation on treatment outcomes.
  • Evaluation of the integration of new technologies like telestroke and artificial intelligence.
  • Examination of stroke-systems-of-care models.

Main Results:

  • Mechanical thrombectomy and thrombolysis have significantly improved outcomes for acute ischemic stroke patients.
  • Collateral circulation is a critical determinant of successful reperfusion and patient outcomes.
  • Technologies such as telestroke, mobile stroke units, and AI are enhancing stroke identification and treatment delivery.
  • Streamlined stroke systems of care facilitate timely revascularization.

Conclusions:

  • Modern acute ischemic stroke care relies on a combination of advanced therapies and patient-specific factors.
  • Collateral status is a crucial consideration for expanding treatment eligibility.
  • Technological innovations and optimized care systems are essential for maximizing the benefits of mechanical thrombectomy.