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Discovery of Driver Genes in Colorectal HT29-derived Cancer Stem-Like Tumorspheres
Published on: July 22, 2020
Data on the evaluation of FGF2 gene expression in Colorectal Cancer
Helena Caiado1,2,3, Natércia Conceição2,3,4, Daniel Tiago2,5
1ProRegeM PhD Programme in Mechanisms of disease and regenerative medicine, University of Algarve, Faro, 8005-139, Portugal.
Abstract:
The data presented in this article is related with the research paper entitled "Evaluation of MGP gene expression in colorectal cancer", available on Gene journal [1]. From all the transcription factors known to regulate MGP, FGF2 is the most described in colon adenocarcinoma and colon tumor cell lines, where it was shown to: i) contribute for the invasiveness potential; and ii) promote proliferation and survival of colorectal cancer cells. These in vitro studies pose the hypothesis that FGF2 associated signaling pathways could be promoting the regulation of others genes, such as MGP, that may lead to tumor progression which ultimately could result in poor prognosis in colon adenocarcinoma.

