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Related Experiment Video

Updated: Dec 18, 2025

An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model
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Human Motion Driven Self-Powered Photodynamic System for Long-Term Autonomous Cancer Therapy.

Zhuo Liu1,2, Lingling Xu1,3, Qiang Zheng1,3

  • 1CAS Center for Excellence in Nanoscience, Beijing Key Laboratory of Micro-nano Energy and Sensor, Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 100083, China.

ACS Nano
|June 20, 2020
PubMed
Summary

This study introduces a self-powered photodynamic therapy (s-PDT) system that harvests energy from body motion. The innovative s-PDT system effectively inhibits tumor growth using two distinct light stimulation modes, offering a promising cancer treatment.

Keywords:
cancer therapyhuman motionphotodynamic therapyself-powered devicewearable

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Oncology

Background:

  • Long-term photodynamic therapy (PDT) for tumors needs a sustainable power source.
  • Current battery or wireless charging methods for PDT devices are inconvenient.
  • Telemedicine demands improved patient compliance and autonomous treatment management.

Purpose of the Study:

  • To develop a self-powered photodynamic therapy (s-PDT) system for autonomous tumor treatment.
  • To investigate two irradiation modes for enhanced therapeutic efficacy.
  • To create a wearable/implantable device for long-term cancer therapy.

Main Methods:

  • Fabrication of an s-PDT system using a twinning structured piezoelectric nanogenerator.
  • Energy harvesting from body motion to power a light-emitting diode (LED).
  • In vitro evaluation using pulsed light stimulation on tumor cells and in vivo testing in mice with transplanted tumors using intermittent continuous light stimulation.

Main Results:

  • The s-PDT system significantly suppressed tumor cell growth in vitro with pulsed light.
  • In vivo studies in mice showed significant antitumor effects with intermittent continuous light stimulation.
  • An 87.46% tumor inhibition rate was achieved in mice over 12 days.

Conclusions:

  • The developed s-PDT system offers a sustainable and autonomous solution for long-term cancer treatment.
  • The dual-mode irradiation capability enhances therapeutic potential.
  • This technology paves the way for self-controllable, wearable/implantable devices for clinical cancer therapy.