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Related Experiment Video

Updated: Dec 18, 2025

Purification of Viral DNA for the Identification of Associated Viral and Cellular Proteins

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Published on: August 31, 2017

Chemokine-binding proteins encoded by herpesviruses.

M Benko, S Lenhartová, V Kempová

Acta Virologica

|June 20, 2020

Summary

Viruses use viral chemokine-binding proteins (vCKBPs) to evade immune responses. Understanding herpesvirus vCKBPs offers potential for treating inflammatory diseases by modulating chemokine activity.

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Last Updated: Dec 18, 2025

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Published on: January 23, 2014

Area of Science:

Immunology
Virology
Molecular Biology

Background:

Pathogens, including viruses, employ strategies to evade host immune systems.
Viruses interact with the host chemokine network to disrupt immune surveillance and promote infection.
Viral immunomodulators, such as viral chemokine-binding proteins (vCKBPs), mimic or bind host chemokines.

Purpose of the Study:

To investigate viral chemokine-binding proteins (vCKBPs) encoded by herpesviruses.
To explore the potential of vCKBPs in modulating chemokine-mediated immune responses.
To identify therapeutic applications of vCKBPs in treating viral infections and inflammatory diseases.

Main Methods:

Focus on vCKBPs encoded by alpha-, beta-, and gamma-herpesviruses.
Review of experimental data on vCKBP function and application in animal models.
Analysis of vCKBP mechanisms in sequestering host chemokines and inhibiting chemotaxis.

Main Results:

Herpesviruses and Poxviruses encode vCKBPs that can sequester host chemokines.
vCKBPs interfere with chemokine gradient formation and ligand-receptor interactions.
Several herpesvirus vCKBPs have demonstrated anti-inflammatory and anti-immune properties in vivo.

Conclusions:

vCKBPs offer a mechanism for viruses to evade immune detection and control.
Herpesvirus vCKBPs can be leveraged to regulate chemokine and chemokine receptor activity.
Targeting vCKBPs presents a promising therapeutic strategy for inflammatory diseases and infections.