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Recent advances in vaccines and diagnostics against Middle East respiratory syndrome coronavirus

K Lee, J H Nam

    Acta Virologica
    |June 20, 2020
    PubMed

    Insights

    Middle East respiratory syndrome coronavirus (MERS-CoV) poses a global threat due to its high mortality and human-to-human transmission. Early detection and vaccine development are crucial for controlling this severe respiratory illness.

    Area of Science:

    • Virology
    • Epidemiology
    • Public Health

    Background:

    • Middle East respiratory syndrome coronavirus (MERS-CoV), identified in 2012, causes severe respiratory disease with high mortality.
    • Over 2500 cases confirmed in 27 countries, with outbreaks like South Korea's 2015 event highlighting global transmission risks.

    Purpose of the Study:

    • To review the transmission dynamics and infection process of MERS-CoV.
    • To summarize current scientific endeavors in developing vaccines and diagnostic tools for MERS-CoV.

    Main Methods:

    • Literature review focusing on MERS-CoV epidemiology and virology.
    • Analysis of scientific publications on vaccine development and diagnostic strategies.

    Main Results:

    • MERS-CoV exhibits significant mortality and potential for global spread through human-to-human transmission.
    • No licensed vaccine currently exists, underscoring the need for effective countermeasures.

    Conclusions:

    • Early detection is paramount for limiting the spread of MERS-CoV.
    • Continued research into MERS-CoV transmission, infection, vaccines, and diagnostics is essential.

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