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Molecular Breast Imaging in Clinical Practice.

Elizabeth H Dibble1, Katie N Hunt2, Eric C Ehman2

  • 1Department of Diagnostic Imaging, The Warren Alpert Medical School of Brown University/Rhode Island Hospital, 593 Eddy St, Providence, RI 02903.

AJR. American Journal of Roentgenology
|June 20, 2020
PubMed
Summary
This summary is machine-generated.

Molecular breast imaging (MBI) finds more cancers in women with dense breasts or high cancer risk. This imaging technique offers a favorable benefit-to-risk ratio, similar to mammography, with minimal radiation exposure.

Keywords:
MBIbreast cancerbreast imagingdense breastsmolecular breast imagingscreening

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Area of Science:

  • Radiology
  • Oncology
  • Medical Imaging

Background:

  • Dense breast tissue can obscure cancers on mammograms.
  • Certain women have an elevated risk for developing breast cancer.

Purpose of the Study:

  • To review the clinical applications of molecular breast imaging (MBI).
  • To guide image interpretation for MBI.
  • To clarify the radiation risks associated with MBI.

Main Methods:

  • Review of existing literature on MBI.
  • Analysis of clinical use cases.
  • Evaluation of MBI's role in cancer risk assessment and treatment response.

Main Results:

  • MBI detects additional cancers missed by conventional imaging, particularly in women with dense breasts and high-risk individuals.
  • MBI is emerging as a valuable imaging biomarker for cancer risk.
  • MBI shows promise in assessing response to neoadjuvant chemotherapy.

Conclusions:

  • MBI offers significant advantages in cancer detection for specific patient populations.
  • The radiation risk from MBI is minimal, with a benefit-to-risk profile comparable to mammography.
  • MBI is a cost-effective, well-tolerated, and clinically adaptable imaging modality.