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Updated: Dec 18, 2025

Tissue Preparation Techniques for Contrast-Enhanced Micro Computed Tomography Imaging of Large Mammalian Cardiac Models with Chronic Disease
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Multimodality Imaging Demonstrating an Apical Variant Hypertrophic Cardiomyopathy in an Uncommon Pentad

Ayman R Fath1, Clinton E Jokerst1, Amro Aglan2

  • 1Mayo Clinic Arizona, Phoenix, AZ, USA.

Journal of Investigative Medicine High Impact Case Reports
|June 20, 2020
PubMed

Insights

This study details a case of apical variant hypertrophic cardiomyopathy discovered during transcatheter aortic valve replacement. Findings included an apical aneurysm, left ventricular gradients, and ascending aorta dilatation.

Area of Science:

  • Cardiology
  • Cardiac Imaging
  • Cardiovascular Surgery

Background:

  • Severe aortic stenosis necessitates intervention, often transcatheter aortic valve replacement (TAVR).
  • Apical variant hypertrophic cardiomyopathy (HCM) is a distinct form of HCM characterized by apical thickening and specific imaging findings.
  • Pre-procedural imaging is crucial for identifying complex cardiac anatomy and comorbidities.

Keywords:
CTapical aneurysmapical hypertrophic cardiomyopathycomputed tomographymid-cavitary obstructiontransthoracic echocardiography

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