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Circadian Rhythms and Gene Regulation

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The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...

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The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...

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Related Experiment Video

Updated: Dec 18, 2025

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

Cell cycle period control through modulation of clock inputs.

S Almeida¹, M Chaves², F Delaunay³

¹Inria, iBV, Université Côte d'Azur, Sophia Antipolis, France.

Journal of Bioinformatics and Computational Biology

|June 20, 2020

Summary

This summary is machine-generated.

This study demonstrates slowing the mammalian cell cycle by coupling it with the cellular clock. Clock inputs effectively modulate cell cycle duration, offering potential therapeutic strategies targeting cell proliferation.

Keywords:

Modeling cell cycle circadian clock period control synchronization

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Last Updated: Dec 18, 2025

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

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Published on: November 11, 2016

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Published on: September 27, 2012

Area of Science:

* Molecular and Systems Biology
* Chronobiology
* Cell Cycle Regulation

Background:

* The mammalian cell cycle and cellular clock are interconnected through molecular mechanisms.
* The CLOCK:BMAL1 complex regulates the *wee1* gene, influencing the cell cycle's mitosis promoting factor (MPF).
* Understanding these interactions is crucial for controlling cell proliferation.

Purpose of the Study:

* To investigate period control of the mammalian cell cycle by coupling it with the cellular clock.
* To explore methods for slowing the cell cycle using clock-based inputs.
* To propose and analyze a model of a Growth Factor (GF)-responsive clock.

Main Methods:

* Utilized mathematical models of cellular clock and cell cycle oscillators.
* Focused on unidirectional coupling dynamics between the clock and cell cycle.
* Investigated synchronization dynamics and period ratios (e.g., 1:1, 3:2).

Main Results:

* Demonstrated successful period control of the cell cycle via clock inputs.
* Observed various rational period ratios between the clock and cell cycle.
* Identified clock modulation protocols capable of slowing the cell cycle.

Conclusions:

* Clock inputs can effectively slow down the mammalian cell cycle.
* The proposed GF-responsive clock model offers new insights.
* Developed protocols show potential for therapeutic applications using existing drugs.