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Author Spotlight: Unveiling the Role of TMOD3 in Platinum Resistance and Immune Infiltration in Ovarian Cancer
Published on: August 2, 2024
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Long non-coding RNA THOR promotes ovarian Cancer cells progression via IL-6/STAT3 pathway.
Jing Ge1,2, Tao Han1,3, Lili Shan1,2
1Department of Gynecology and Obstetrics, Second Affiliated Hospital of Dalian Medical University, Dalian, 116023, Liaoning Province, China.
Journal of Ovarian Research
|June 20, 2020
Summary
Testis-associated highly conserved oncogenic long non-coding RNA (THOR) promotes ovarian cancer growth and metastasis. Inhibiting THOR or the IL-6/STAT3 pathway may offer new therapeutic strategies for ovarian cancer.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Ovarian cancer (OC) has a poor prognosis due to late diagnosis and metastasis.
- The oncogenic role of testis-associated highly conserved oncogenic long non-coding RNA (THOR) is known in other cancers, but its function in OC is unclear.
Purpose of the Study:
- To investigate the role of THOR in ovarian cancer progression.
- To explore THOR as a potential prognostic marker and therapeutic target in OC.
Main Methods:
- Detected THOR, p-STAT3, and IL-6 expression using RT-PCR and Western blot.
- Assessed THOR's impact on OC cell proliferation, metastasis, and self-renewal in vitro and in vivo.
- Analyzed THOR's prognostic value in OC patient cohorts.
Main Results:
- THOR is significantly upregulated in OC tissues and correlates with poor prognosis.
- Knockdown of THOR inhibits OC cell growth, metastasis, and self-renewal.
- THOR promotes OC progression by activating the IL-6/STAT3 signaling pathway.
Conclusions:
- THOR promotes OC cell growth, metastasis, and self-renewal via IL-6/STAT3 activation.
- THOR is a potential predictive factor and therapeutic target for ovarian cancer.
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