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Neutrophil activation identifies patients with active polyarticular gout
D Vedder1,2, M Gerritsen3, B Duvvuri4
1Amsterdam Rheumatology & Immunology Center, Reade, 1056 AB, Amsterdam, Netherlands. d.vedder@reade.nl.
Arthritis Research & Therapy
|June 20, 2020
Summary
Neutrophil activation markers, including peroxidase and calprotectin, are linked to active, polyarticular gout. Neutrophil extracellular traps (NETs) are present but do not correlate with disease activity, suggesting potential clinical utility for peroxidase and calprotectin in monitoring gout.
Area of Science:
- Rheumatology
- Immunology
- Biochemistry
Background:
- Gout is a prevalent inflammatory arthritis driven by neutrophil activation and crystal phagocytosis.
- This process leads to synovitis, joint damage, and systemic inflammation.
Purpose of the Study:
- To investigate the clinical utility of neutrophil-derived biomarkers in reflecting gout disease activity.
- To determine if biomarkers from activated neutrophils can serve as indicators of gout disease status.
Main Methods:
- Compared plasma samples from 75 gout patients and 30 healthy controls.
- Analyzed levels of neutrophil extracellular traps (NETs), calprotectin, and peroxidase activity.
- Correlated biomarker levels with markers of inflammation and gout disease activity.
Main Results:
- Neutrophil activation markers (NETs, calprotectin, peroxidase) were elevated in gout patients versus controls.
- Peroxidase activity correlated with disease activity scores and inflammation markers (CRP, ESR).
- Calprotectin correlated with CRP and morning stiffness, particularly in chronic polyarticular gout.
Conclusions:
- Neutrophil activation markers are associated with active, polyarticular gout.
- NETs are present in gout patients' blood but do not correlate with disease activity.
- Peroxidase and calprotectin show potential as clinical biomarkers for monitoring gout activity.
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