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Updated: Dec 18, 2025

Stereotaxic Surgery for Genetic Manipulation in Striatal Cells of Neonatal Mouse Brains

Stereotaxic Surgery for Genetic Manipulation in Striatal Cells of Neonatal Mouse Brains

Published on: July 10, 2018

Combinatorial Developmental Controls on Striatonigral Circuits.

Ayano Matsushima¹, Ann M Graybiel¹

¹McGovern Institute for Brain Research and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 20139, USA.

|June 20, 2020

Summary

This summary is machine-generated.

Striatal projection neurons (SPNs) in mice show distinct wiring logic. Axon targeting within the substantia nigra pars compacta depends on both neuron location and birth date, influencing circuitry and disease vulnerability.

Keywords:

Dlx1 birth date cell-fate mapping matrix ontogenesis unit striatal disorders striatum striosome

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Area of Science:

Neuroscience
Developmental Biology
Neuroanatomy

Background:

Cortical pyramidal cells develop locally, forming distinct functional areas.
Striatal projection neurons (SPNs) originate remotely, migrate, and form striosomes and matrix within functionally distinct sectors.
Striatal circuit development may differ from neocortical organization.

Purpose of the Study:

To investigate the unique developmental organization of striatal circuits.
To map striatal projection neurons (SPNs) with striatonigral projections to the substantia nigra pars compacta (SNpc) in mice.

Main Methods:

Mapping striatonigral projections from SPNs in specific striatal sectors.
Analyzing topographic projection patterns based on SPN age and location.

Main Results:

Same-age SPNs demonstrate topographic projections to the SNpc based on their location.
SPNs born at different times within the same sector project to distinct destinations within the SNpc.
This reveals a developmental logic integrating birth date-dependent and independent factors.

Conclusions:

Striatal circuit organization involves a complex interplay of developmental factors.
Axon trajectory determination in SPNs is influenced by both location and birth timing.
This organized circuitry may impact behavior and susceptibility to neurological diseases.