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Genetically modified immune cells targeting tumor antigens

Mansour Poorebrahim1, Mohammad Foad Abazari2, Solmaz Sadeghi3

  • 1Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.

Pharmacology & Therapeutics
|June 20, 2020
PubMed

Immunotherapy approaches consisting of genetically modified immune cells have become a promising platform for cancer treatment. Such 'living' therapies targeting tumor antigens have shown success in many cancer patients in the form of durable responses in a growing number of clinical studies. Besides, a large number of ongoing studies have been designed to introduce reliable methods for identification of tumor antigens. In addition, technical and biotechnological developments are being applied to the generation and expansion of genetically modified immune cells. In this review, we summarize and discuss the latest progress and current challenges in the tumor antigen landscape and in the generation of genetically modified immune cells in view of their clinical efficacy, either as monotherapy or combinational therapy.

Keywords:
Genetically modified immune cellTumor antigen‘Living’ therapy

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