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Protocol for Recombinant RBD-based SARS Vaccines: Protein Preparation, Animal Vaccination and Neutralization Detection
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Multisystem Inflammatory Syndrome in Children Associated with Severe Acute Respiratory Syndrome Coronavirus 2

Shubhi Kaushik1, Scott I Aydin2, Kim R Derespina3

  • 1Department of Pediatrics, Division of Pediatric Critical Care Medicine, Mount Sinai Kravis Children's Hospital, Icahn School of Medicine at Mount Sinai, New York, NY.

The Journal of Pediatrics
|June 20, 2020
PubMed

Insights

Multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19 presents diverse symptoms and cardiac involvement. However, most children experience rapid recovery with intensive supportive care.

Area of Science:

  • Pediatric critical care medicine
  • Infectious diseases
  • Cardiology

Background:

  • Multisystem inflammatory syndrome in children (MIS-C) is a rare but serious condition linked to COVID-19.
  • Understanding the clinical spectrum and outcomes of MIS-C is crucial for timely management.

Purpose of the Study:

  • To evaluate the clinical characteristics and outcomes of children diagnosed with MIS-C.
  • To identify key indicators of severity and recovery in pediatric MIS-C patients.

Main Methods:

  • Retrospective analysis of 33 children with MIS-C admitted to New York City pediatric intensive care units.
  • Collection and review of demographic, clinical, laboratory, and treatment data.

Main Results:

  • Fever and vomiting were common symptoms; 63% had depressed left ventricular ejection fraction.
  • Elevated inflammatory markers (CRP, procalcitonin, d-dimer) were universal.
  • Most patients received intensive care, including IVIG, corticosteroids, and vasopressors; 95% with cardiac dysfunction showed normalization of ejection fraction.

Conclusions:

  • Children with COVID-19-associated MIS-C exhibit a broad range of severity requiring intensive supportive care.
  • Rapid and complete clinical and myocardial recovery is nearly universal with appropriate management.
Abstract

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