Cardiovascular Outcomes in Young Adulthood in a Population-Based Very Low Birth Weight Cohort

To assess differences in left heart structure and function, and endothelial function in a national cohort of very low birth weight (VLBW) young adults and term-born controls.

The New Zealand VLBW study is a prospective, population-based, longitudinal cohort study which included all infants born <1500 g in 1986. The VLBW cohort (n = 229; 71% of survivors) and term-born controls (n = 100), were assessed at age 26-30 years. Measures of left heart structure and function were evaluated by echocardiography, vascular function was assessed using blood pressure, reactive hyperemia index, and arterioventricular coupling by calculating left ventricular (LV) and arterial elastance.

Compared with controls, those born VLBW had smaller LVs, even when indexed for body surface area (mean LV mass, 89.7 ± 19.3 g/m² vs 95.0 ± 22.3 g/m² [P = .03]; LV end-diastolic volume, 58.3 ± 10.9 mL/m² vs 62.4 ± 12.4 mL/m² [P = .002]; and LV end-systolic volume, 20.8 ± 4.9 mL/m² vs 22.6 ± 5.8 mL/m² [P = .004]). VLBW participants had lower stroke volume (median, 37.2 mL/m² [IQR, 33-42 mL/m²] vs median, 40.1 mL/m² [IQR, 34-45 mL/m²]; P = .0059) and cardiac output (mean, 4.8 ± 1.2 L/min vs 5.1 ± 1.4 L/min; P = .03), but there was no difference in ejection fraction. The VLBW group had higher LV elastance (3.37 ± 0.88 mm Hg/mL vs 2.86 ± 0.75 mm Hg/mL; P < .0001) and arterial elastance (1.84 ± 0.4 vs 1.6 ± 0.4; P < .0001) and lower reactive hyperemia index (0.605 ± 0.28 vs 0.688 ± 0.31; P = .041). These measures were influenced by birth weight and sex, but we found limited associations with other perinatal factors.

Being born preterm and VLBW is associated with differences in cardiovascular structure and function in adulthood. This population may be more vulnerable to cardiovascular pathology as they age.

Australian Clinical Trials Registry ACTRN12612000995875.