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"Liver-on-a-Chip" Cultures of Primary Hepatocytes and Kupffer Cells for Hepatitis B Virus Infection
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Characteristics of Liver Function in Patients With SARS-CoV-2 and Chronic HBV Coinfection

Xiaojing Zou1, Minghao Fang1, Shusheng Li1

  • 1Department of Emergency, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
|June 20, 2020
PubMed

Insights

COVID-19 patients with chronic hepatitis B virus (HBV) coinfection frequently experienced liver injury, which was linked to severe disease and worse outcomes. Frequent liver function monitoring is crucial for these patients.

Area of Science:

  • Hepatology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Coronavirus disease 2019 (COVID-19) poses a significant global health challenge.
  • Hepatitis B virus (HBV) infection is a prevalent chronic condition worldwide.
  • Understanding the interplay between SARS-CoV-2 and chronic HBV is critical for patient management.

Purpose of the Study:

  • To characterize liver function abnormalities in patients coinfected with SARS-CoV-2 and chronic HBV.
  • To investigate the association between liver dysfunction and COVID-19 severity and prognosis in this coinfected population.

Main Methods:

  • A cohort of 105 adult patients with SARS-CoV-2 and chronic HBV coinfection was studied.
  • Demographic, clinical, laboratory, treatment, and outcome data were collected.
  • Liver function tests and their correlation with disease severity and prognosis were analyzed.

Main Results:

  • Elevated liver enzymes and bilirubin were observed in a significant proportion of patients at admission and increased during hospitalization.
  • 13.33% of patients developed liver injury, with 28.57% progressing to acute-on-chronic liver failure.
  • Liver injury was associated with a higher incidence of severe COVID-19, complications, and increased mortality.

Conclusions:

  • Liver injury in SARS-CoV-2/chronic HBV coinfected patients is linked to disease severity and poor prognosis.
  • Close monitoring and frequent evaluation of liver function are essential during COVID-19 treatment for patients with chronic HBV.
Abstract

Keywords:
COVID-19HBVLiver InjurySARS-CoV-2

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