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Interatrial block and its association with an increased risk of ischemic stroke: A systematic review and

Narut Prasitlumkum1, Wisit Cheungpasitporn2, Raktham Mekritthikrai1

  • 1Department of Medicine, University of Hawaii, Honolulu, HI, USA.

Journal of Electrocardiology
|June 20, 2020
PubMed

Insights

Advanced interatrial block (IAB) significantly increases stroke risk, while partial IAB does not. History of stroke modifies this risk, highlighting the need for further research in stroke risk stratification.

Area of Science:

  • Cardiology
  • Neurology
  • Epidemiology

Background:

  • Interatrial block (IAB) has been suggested to associate with ischemic stroke risk.
  • No comprehensive systematic review and meta-analysis has previously assessed this relationship.

Purpose of the Study:

  • To conduct a systematic review and meta-analysis to evaluate the association between interatrial block (IAB) and ischemic stroke.
  • To determine if different types of IAB (partial vs. advanced) pose varying risks for stroke.

Main Methods:

  • A systematic search of MEDLINE, EMBASE, PUBMED, and Cochrane databases was performed up to January 2020.
  • Included were observational studies comparing ischemic stroke risk in patients with and without IAB.
  • Data were pooled using random-effects models to calculate risk ratios and 95% confidence intervals (CIs).

Main Results:

  • Ten studies with 177,249 participants were analyzed.
  • Advanced IAB was associated with an increased risk of stroke (OR 1.85, 95% CI 1.37-2.50, p < 0.001).
  • Partial IAB showed no significant association with increased stroke risk (OR 1.19, 95% CI 0.99-1.43, p = 0.054).
  • Subgroup analysis indicated a higher risk of recurrent stroke in patients with prior stroke, particularly those with advanced IAB (OR 4.73).

Conclusions:

  • Only advanced interatrial block is significantly associated with an increased risk of stroke.
  • A history of stroke may modify the relationship between IAB and recurrent stroke risk.
  • Further research is needed to confirm these findings for clinical stroke risk stratification.
Abstract

Keywords:
Interatrial blockIschemic stroke

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