COVID-19 prevention and multiple sclerosis management: The SAFE pathway for the post-peak
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Updated: Dec 18, 2025

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool
Published on: June 30, 2014
Antonio Buonomo1, Vincenzo Brescia Morra2, Emanuela Zappulo1
1Section of Infectious Diseases, Department of Clinical Medicine and Surgery, Federico II University of Naples, Italy.
Insights
This study outlines a protocol for managing multiple sclerosis (MS) during the COVID-19 pandemic. It includes recommendations for MS center access and pre-treatment isolation and testing to ensure patient safety.
Area of Science:
- Neurology
- Infectious Diseases
Background:
- The COVID-19 pandemic necessitated adaptations in healthcare delivery.
- Naples, Italy, experienced its COVID-19 peak, providing a context for this study.
Discussion:
- The protocol addresses the long-term management of multiple sclerosis (MS) amidst ongoing COVID-19 circulation.
- It integrates logistic, preventative, and clinical recommendations for MS care.
Key Insights:
- A pathway for MS center access was established.
- Mandatory 14-day self-isolation and COVID-19 testing were incorporated before specific disease-modifying treatments.
- This approach aims to minimize transmission risks for vulnerable MS patients.
Outlook:
- The developed protocol offers a practical framework for MS management during the pandemic.
- It is anticipated to be valuable for other MS centers facing similar challenges.
Background:
We hereby report on our experience from Naples (South Italy), where the peak of coronavirus disease 2019 (COVID-19) has already passed.
Methods:
Assuming that COVID-19 will be circulating until vaccination and/or herd immunity is achieved (possibly not earlier than 2021), we have developed a protocol for the long-term management of multiple sclerosis (MS).
Results:
We have defined a pathway for the access to the MS Centre with logistic, preventative and clinical recommendations, and have also included 14-day self-isolation and COVID-19 testing before some disease modifying treatments.
Discussion:
Overall, we believe our experience could be helpful for MS management in the upcoming months.
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