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Inversion of natural immuno-hormonal interactions under influence of antibodies against environmental chemical
Andrew N Glushkov1, Elena G Polenok1, Stella A Mun1
1Institute of Human Ecology, Federal Research Center of Coal and Coal Chemistry of Siberian Branch of the Russian Academy of Sciences, Kemerovo 650065, Russian Federation.
Abstract:
In this article we present a hypothesis that interactions between sex hormones and specific antibodies change inversely in presence of antibodies against environmental carcinogens. Natural occurrence antibodies to estradiol (E2) and progesterone (Pg) do not influence on E2 concentration, but antibodies to Pg increase Pg concentration in blood serum of postmenopausal healthy women with low levels of antibodies against benzo[a]pyrene (Bp). Thereby natural occurrence antibodies to Pg inhibit the promotion of breast carcinogenesis. Antibodies to E2 and Pg increase E2 concentration but decrease Pg concentration when the levels of antibodies to Bp are high. Therefore, antibodies against Bp switch hormonal effects of antibodies to E2 and Pg from the increase of Pg concentration to the increase of E2, thus stimulating breast cancer promotion. These immuno-hormonal interactions are weaker in breast cancer patients, probably due to corresponding anti-idiotypic antibodies.
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