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Related Experiment Videos

Plasma cortisol and depression in pathological gamblers.

L F Ramirez1, R A McCormick, M T Lowy

  • 1Department of Psychiatry, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106.

The British Journal of Psychiatry : the Journal of Mental Science
|November 1, 1988
PubMed
Summary
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Pathological gamblers showed significant cortisol level fluctuations linked to depression symptoms. This suggests a distinct subtype of pathological gambling with clinical implications.

Area of Science:

  • Endocrinology
  • Psychiatry
  • Behavioral Science

Background:

  • Pathological gambling is associated with depression.
  • Cortisol dysregulation may play a role in psychiatric disorders.
  • Previous research linked psychological measures to depression in gamblers.

Purpose of the Study:

  • To investigate basal serum cortisol and dexamethasone suppression test (DST) results in pathological gamblers.
  • To explore the relationship between cortisol levels and psychological measures (Beck Depression Inventory, Minnesota Multiphasic Personality Inventory).

Main Methods:

  • Studied 21 pathological gamblers.
  • Measured basal serum cortisol at 08:00 h and 16:00 h.
  • Administered the Beck Depression Inventory and Minnesota Multiphasic Personality Inventory scales.

Related Experiment Videos

  • Performed dexamethasone suppression tests (DST).

    • Main Results:

    • All subjects were suppressors on the DST.
    • A significant relationship was found between diurnal cortisol fluctuation and psychological measures.
    • Cortisol level variability correlated with depression indicators in pathological gamblers.

    Conclusions:

    • Diurnal cortisol fluctuation may indicate a specific subtype of pathological gambling.
    • This subtype may have clinical significance for understanding and treating pathological gambling.
    • Further research is warranted to explore the neuroendocrine underpinnings of pathological gambling subtypes.