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Updated: Dec 18, 2025

Imaging Approaches to Assessments of Toxicological Oxidative Stress Using Genetically-encoded Fluorogenic Sensors
Published on: February 7, 2018
4-hydroxynonenal and oxidative stress in several organelles and its damaging effects on cell functions
G Gallo1, P Sprovieri2, G Martino2
1Department of Biology, Ecology, and Earth Sciences, University of Calabria, Rende, (CS), Italy. gg9495824@gmail.com.
Abstract:
This review aims to describe the action sites of the oxidative stress products for 4-hydroxy-2E-nonenal, on subcellular fractions of eukaryotic cells from several tissues. Described also are; the detoxification mechanisms from derivatives of 4-hydroxy-2E-nonenal. All dangerous compounds for subcellular fractions are metabolites of a respiratory chain that can give stable products of oxidative compounds and are intermediates of other oxidation reaction chains. Finally, the balancing among the illustrated processes to identify the relative oxidative power of several metabolic chains useful to make evident subcellular damages or detoxification processes is discussed.
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