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Detection of Architectural Distortion in Prior Mammograms via Analysis of Oriented Patterns

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Published on: August 30, 2013

Quantitative Analysis of Enhancement Intensity and Patterns on Contrast-enhanced Spectral Mammography.

Ying Liu¹, Shuang Zhao¹, Juan Huang¹

¹Department of Radiology, Sichuan University West China Hospital, No. 37 Guoxue Alley, Chengdu, 610041, Sichuan Province, China.

Scientific Reports

|June 20, 2020

Summary

Quantitative analysis of contrast-enhanced mammography (CESM) enhancement intensity improves breast cancer diagnosis specificity. This method aids in differentiating malignant from benign lesions and assessing hormonal receptor status, enhancing diagnostic accuracy.

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Area of Science:

Radiology
Medical Imaging
Oncology

Background:

Contrast-enhanced mammography (CESM) offers high breast cancer detection rates but limited specificity.
Improving diagnostic specificity is crucial for effective breast cancer management.

Purpose of the Study:

To quantitatively assess CESM enhancement intensity in breast lesions with varying pathologies and hormonal receptor statuses.
To evaluate the consistency of enhancement patterns between CESM and DCE-MRI.

Main Methods:

Quantitative analysis of enhancement intensity and patterns in 145 breast lesions (43 malignant, 99 benign) using CESM.
Comparison of diagnostic performance based on enhancement intensity.
Assessment of enhancement intensity in relation to pathological and hormonal receptor status (ER, PR, HER-2).
Evaluation of agreement between CESM and DCE-MRI in 28 patients.

Main Results:

Quantitative enhancement intensity analysis showed higher diagnostic performance than qualitative assessment (AUC: 0.834 vs. 0.755).
Infiltrating cancers exhibited the highest enhancement intensity, while benign lesions showed the lowest.
Hormonal receptor status influenced enhancement intensity: ER/PR-positive lesions were weaker, HER-2-positive lesions were stronger.
CESM and DCE-MRI showed a 64.2% coincidence rate and moderate agreement (k=0.515).

Conclusions:

Quantitative analysis of enhancement characteristics in CESM is a feasible and valuable tool for improving diagnostic accuracy in breast lesion assessment.
CESM enhancement patterns correlate with lesion pathology and hormonal receptor status, aiding in differential diagnosis.