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[Coagulopathy in COVID-19: pathophysiology]

Simona Pierini1, Eufemia Incampo1, Daniela Bokor1

  • 1U.O.C. Cardiologia-UTIC.

Giornale Italiano Di Cardiologia (2006)
|June 20, 2020
PubMed

Insights

The COVID-19 pandemic is linked to systemic inflammation, causing blood clotting issues and venous thromboembolism. Understanding these coagulopathy mechanisms is crucial for future treatments.

Area of Science:

  • Medicine
  • Pathophysiology
  • Infectious Diseases

Background:

  • The World Health Organization declared COVID-19 a pandemic on March 11, 2020.
  • Italian physicians were among the first to manage COVID-19 patients.
  • Clinical observations revealed a systemic inflammatory response alongside respiratory symptoms.

Purpose of the Study:

  • To review the literature on COVID-19-associated coagulopathy.
  • To understand the pathophysiological mechanisms of COVID-19-induced coagulation disorders.
  • To inform future clinical and therapeutic strategies.

Main Methods:

  • Literature review of available scientific publications.
  • Analysis of clinical observations regarding COVID-19 and coagulation.
  • Synthesis of pathophysiological insights into coagulopathy.

Main Results:

  • COVID-19 involves a systemic inflammatory response.
  • This inflammation leads to coagulation disorders.
  • Complications include venous thromboembolism and other thrombotic events.

Conclusions:

  • Coagulopathy is a significant complication of COVID-19.
  • Further understanding of its mechanisms is needed.
  • This knowledge will guide clinical management and therapy development.

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