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Published on: October 10, 2016
A lysozyme corona complex for the controlled pharmacokinetic release of probucol from mesoporous silica particles
Kalpeshkumar Giri1, Michael Lau, Inga Kuschnerus
1Dpt. Molecular Sciences, Macquarie University, Sydney, NSW, Australia. alf.garcia@mq.edu.au.
Abstract:
Mesoporous silica particles (MSPs) enhance the release kinetics of poorly soluble compound probucol (PB) under the influence of a pore-blocking protein corona, prepared with lysozyme protein adsorption. In vivo oral administration experiments show a prolongation in the time to reach maximum systemic concentration and half-life of PB released from the lysozyme-MSP complex in comparison to the MSP alone. Specific hard protein corona complexes can act as functional diffusion barriers for the controlled release of drugs from MSP based formulations.
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