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Revisiting respiratory syncytial virus's interaction with host immunity, towards novel therapeutics

C Efstathiou1, S H Abidi2, J Harker3

  • 1School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.

Cellular and Molecular Life Sciences : CMLS
|June 20, 2020
PubMed

Insights

Respiratory Syncytial Virus (RSV) causes millions of childhood infections annually, yet no effective treatments exist. Understanding RSV

Area of Science:

  • Immunology
  • Virology
  • Pediatrics

Background:

  • Respiratory Syncytial Virus (RSV) is a leading cause of lower respiratory tract infection (LRTI) in infants globally.
  • Over 33 million children under five experience RSV-related infections yearly, with 99% of mortality in low/middle-income countries.
  • Despite being identified 62 years ago, effective treatments or vaccines for RSV are still lacking, posing risks to infants, the elderly, and immunocompromised individuals.

Purpose of the Study:

  • To review the complex interactions between RSV and the host immune system.
  • To consolidate current knowledge on RSV's immune evasion strategies.
  • To identify pathways for developing effective antiviral therapies and vaccines.

Main Methods:

  • Literature review of existing research on RSV immunology.
  • Analysis of host immune response modulation by RSV.
  • Synthesis of data on viral pathogenesis and immune evasion.

Main Results:

  • RSV employs intricate mechanisms to evade and modulate host immune responses.
  • A detailed understanding of these interactions is crucial for therapeutic development.
  • Current knowledge highlights specific immune pathways targeted by RSV.

Conclusions:

  • Further research into RSV-host immune interactions is essential.
  • This knowledge can guide the development of novel treatments and vaccines.
  • Combating the global threat of RSV requires a focused approach on its immunomodulation.

Keywords:
ImmunityInterferonRSVTherapeutics

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