Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Liver Regeneration01:24

Liver Regeneration

4.1K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
4.1K
Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

1.7K
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
1.7K
Hepatic Portal System01:21

Hepatic Portal System

4.6K
The hepatic portal system, a critical part of our circulatory framework, transports nutrient-laden, deoxygenated blood from the gastrointestinal tract and spleen to the liver. This ingenious system plays an indispensable role in maintaining our body's metabolic equilibrium.
At its core, the hepatic portal vein is the result of a confluence of the superior and inferior mesenteric veins along with the splenic vein. Each of these veins has a unique role. The superior mesenteric vein is...
4.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Delaying surgery beyond six weeks after systemic therapy reduces postoperative morbidity without evidence of impaired oncologic outcomes in colorectal liver metastases.

BMC cancer·2026
Same author

A Serum lncRNA Signature Determines Oncogenic YAP Activity in Cancer Patients.

International journal of cancer·2026
Same author

[Detection and differentiation of atypical hepatocellular carcinomas].

Radiologie (Heidelberg, Germany)·2026
Same author

Histopathology matters for imaging and clinical correlations in primary sclerosing cholangitis.

Journal of hepatology·2026
Same author

Relative Exchangeable and Exchangeable Copper: Emerging New Biomarkers for Diagnosis and Therapy Monitoring in Wilson's Disease.

Liver international : official journal of the International Association for the Study of the Liver·2026
Same author

Author Correction: A complex secretory program orchestrated by the inflammasome controls paracrine senescence.

Nature cell biology·2026
Same journal

[Connective (tissue) pathology: What brings us together!]

Der Pathologe·2022
Same journal

[Giant cell-containing tumors of bone and differential diagnoses].

Der Pathologe·2022
Same journal

[Automation and application of robotics in the pathology laboratory].

Der Pathologe·2022
Same journal

[Practical diagnostic aspects of uterine leiomyosarcoma in the context of the 2020 WHO classification].

Der Pathologe·2022
Same journal

[Artificial intelligence: a solution for the lack of pathologists?]

Der Pathologe·2022
Same journal

[Predictive immunocytochemistry in non-small cell lung carcinoma].

Der Pathologe·2022
See all related articles

Related Experiment Video

Updated: Dec 18, 2025

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
12:24

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

Published on: September 30, 2021

5.8K

[Hepatocellular carcinoma].

Thomas Longerich1

  • 1Pathologisches Institut, Uniklinikum Heidelberg, Im Neuenheimer Feld 224, 69120, Heidelberg, Deutschland. thomas.longerich@med.uni-heidelberg.de.

Der Pathologe
|June 20, 2020
PubMed
Summary
This summary is machine-generated.

Hepatocellular carcinoma (HCC), a deadly cancer, can be diagnosed early using specific markers. New WHO classifications identify HCC subtypes based on histology and molecular features for personalized treatment.

Keywords:
Hepatocellular carcinomaHistologyMolecular pathologySubtypeWorld Health Organization

More Related Videos

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
06:38

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis

Published on: September 12, 2019

9.3K
Exploring the Potential of Mesenchymal Stem Cell Sheet on The Development of Hepatocellular Carcinoma In Vivo
10:18

Exploring the Potential of Mesenchymal Stem Cell Sheet on The Development of Hepatocellular Carcinoma In Vivo

Published on: September 11, 2018

6.1K

Related Experiment Videos

Last Updated: Dec 18, 2025

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
12:24

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

Published on: September 30, 2021

5.8K
An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
06:38

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis

Published on: September 12, 2019

9.3K
Exploring the Potential of Mesenchymal Stem Cell Sheet on The Development of Hepatocellular Carcinoma In Vivo
10:18

Exploring the Potential of Mesenchymal Stem Cell Sheet on The Development of Hepatocellular Carcinoma In Vivo

Published on: September 11, 2018

6.1K

Area of Science:

  • Hepatology
  • Oncology
  • Cancer Research

Background:

  • Hepatocellular carcinoma (HCC) is a leading cause of cancer death globally.
  • Chronic viral hepatitis and steatohepatitis are primary risk factors, progressing through liver cirrhosis and preneoplastic lesions.
  • Accurate differentiation of early HCC from precursor lesions is crucial for patient outcomes.

Purpose of the Study:

  • To explore the association between histological features and molecular subgroups in human HCC.
  • To highlight the clinical relevance of recent WHO classification updates for liver cancer.
  • To evaluate the potential of newly defined HCC subtypes in precision oncology.

Main Methods:

  • Application of strict morphological criteria for histological assessment.
  • Utilizing a panel of immunohistological markers for diagnostic differentiation.
  • Integrative characterization of histological and molecular data.

Main Results:

  • Early HCC can be distinguished from precursor lesions and other hepatocellular lesions using morphological and immunohistological methods.
  • Histological features are associated with specific molecular subgroups within HCC.
  • The updated WHO classification introduces distinct HCC subtypes based on combined histological and molecular characteristics.

Conclusions:

  • Recent advancements allow for precise differentiation of HCC and its precursor lesions.
  • The newly defined HCC subtypes exhibit unique biological and clinical behaviors.
  • The classification of HCC subtypes may pave the way for precision oncology in HCC management, requiring further monitoring.