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Analysis of HLA-G protein expression in leprosy
Camila Rodrigues da Silva1, Lucas Henrique Ferreira Sampaio2, Maurício Barcelos Costa1
1Universidade Federal de Goiás (UFG), Goiânia, Goiás, Brazil.
Abstract:
The aim of this study was to evaluate the expression of human leukocyte antigen G (HLA-G) in leprosy. Biopsy and serum samples were collected from 18 patients presenting with leprosy and from healthy controls. Samples were analyzed using immunohistochemistry and ELISA techniques. HLA-G expression was observed in biopsy samples of all patients. The healthy control samples were consistently negative for HLA-G expression. Control plasma samples displayed significantly higher HLA-G expression than those from the patients (p < 0.01). These results are the first demonstration of the expression of HLA-G in leprosy.
