Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

261
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
261
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

2.5K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
2.5K
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

317
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
317
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

573
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
573
Pulmonary Hypertension: Classification and Pathogenesis01:30

Pulmonary Hypertension: Classification and Pathogenesis

479
Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
479
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

255
Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
255

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Influence of the Outflow Graft Angular Position on the Outcomes in Patients With a Left Ventricular Assist Device.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2024
Same author

Male-female differences in contemporary elective ascending aortic surgery: insights from the Netherlands Heart Registration.

Annals of cardiothoracic surgery·2023
Same author

Aortic arch branching variations and risk of cerebrovascular accidents in patients with a left ventricular assist device.

Journal of cardiovascular medicine (Hagerstown, Md.)·2023
Same author

Long term outcome after surgical ASD-closure at young age: Longitudinal follow-up up to 50 years after surgery.

International journal of cardiology·2023
Same author

Long-term surgical outcomes of congenital supravalvular aortic stenosis: a systematic review, meta-analysis and microsimulation study.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery·2023
Same author

Aortic valve repair in neonates, infants and children: a systematic review, meta-analysis and microsimulation study.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery·2023

Related Experiment Video

Updated: Dec 18, 2025

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography
07:11

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography

Published on: October 28, 2020

3.2K

Right ventricular phenotype, function, and failure: a journey from evolution to clinics.

Yannick J H J Taverne1,2,3, Amir Sadeghi4, Beatrijs Bartelds5

  • 1Department of Cardiothoracic Surgery, Erasmus University Medical Center, Room Rg627, Dr. Molewaterplein 40, 3015, GD, Rotterdam, The Netherlands. y.j.h.j.taverne@erasmusmc.nl.

Heart Failure Reviews
|June 20, 2020
PubMed
Summary

The right ventricle (RV), unlike the left, has unique origins, anatomy, and contraction patterns. Understanding RV failure requires integrating evolutionary, molecular, and biomechanical factors for a complete clinical picture.

Keywords:
Adoptive alterationsEvolutionary proxiesFunctional anatomySpecific right ventricular biomechanics

More Related Videos

Chronic Ovine Model of Right Ventricular Failure and Functional Tricuspid Regurgitation
08:43

Chronic Ovine Model of Right Ventricular Failure and Functional Tricuspid Regurgitation

Published on: March 17, 2023

923
Author Spotlight: Establishment and Confirmation of a Postnatal Right Ventricular Volume Overload Mouse Model
06:04

Author Spotlight: Establishment and Confirmation of a Postnatal Right Ventricular Volume Overload Mouse Model

Published on: June 9, 2023

1.4K

Related Experiment Videos

Last Updated: Dec 18, 2025

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography
07:11

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography

Published on: October 28, 2020

3.2K
Chronic Ovine Model of Right Ventricular Failure and Functional Tricuspid Regurgitation
08:43

Chronic Ovine Model of Right Ventricular Failure and Functional Tricuspid Regurgitation

Published on: March 17, 2023

923
Author Spotlight: Establishment and Confirmation of a Postnatal Right Ventricular Volume Overload Mouse Model
06:04

Author Spotlight: Establishment and Confirmation of a Postnatal Right Ventricular Volume Overload Mouse Model

Published on: June 9, 2023

1.4K

Area of Science:

  • Cardiovascular Biology
  • Developmental Biology
  • Evolutionary Medicine

Background:

  • The right ventricle (RV) is often overlooked, despite its distinct cellular origins, complex 3D structure, and unique contraction patterns compared to the left ventricle (LV).
  • Current understanding of right ventricular failure mechanisms, detection, and responses to pressure/volume overload remains incomplete.
  • RV physiology and morphology are deeply rooted in evolutionary processes and early cardiac development.

Purpose of the Study:

  • To provide a comprehensive understanding of right ventricular (mal)adaptation and failure.
  • To integrate evolutionary, developmental, molecular, cellular, biomechanical, and anatomical perspectives on RV function.
  • To highlight the limitations of studying RV contraction patterns in isolation.

Main Methods:

  • Review of evolutionary biology and cardiac development.
  • Analysis of molecular and cellular pathways in cardiac formation.
  • Examination of biomechanical and anatomical differences between RV and LV.
  • Integration of clinical presentations of RV failure.

Main Results:

  • The RV originates from different precursor cells than the LV, leading to distinct biomechanical properties.
  • Cardiac development in early fetal life recapitulates aspects of cardiac evolution.
  • Complex interactions between cardiogenic pathways and tissue-specific cofactors drive cardiac complexity and RV-specific features.

Conclusions:

  • A holistic approach, considering evolution to clinical presentation, is crucial for understanding RV (mal)adaptation and failure.
  • RV biomechanics are intrinsically linked to its unique developmental and evolutionary history.
  • Future research must adopt a multi-layered, three-dimensional perspective to fully elucidate RV function and pathology.