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Posterior pole retinal thickness distribution pattern in keratoconus.

Ali Mahdavi Fard1, Sangita P Patel1,2, Raana Daei Sorkhabi3

  • 1Department of Ophthalmology, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY, USA.

International Ophthalmology
|June 20, 2020
PubMed
Summary
This summary is machine-generated.

Patients with keratoconus (KCN) show increased posterior pole retinal thickness correlated with disease severity. This suggests retinal plasticity in response to KCN, a condition affecting the anterior segment.

Keywords:
Anterior segmentKeratoconusKeratometryOptical coherence tomographyPosterior pole retinal thickness

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Area of Science:

  • Ophthalmology
  • Retinal Imaging
  • Corneal Diseases

Background:

  • Keratoconus (KCN) is a progressive corneal ectasia affecting the anterior segment.
  • The impact of KCN on posterior segment structures, specifically retinal thickness, is not well understood.
  • Understanding retinal changes in KCN may offer insights into ocular plasticity.

Purpose of the Study:

  • To evaluate retinal thickness distribution patterns in keratoconus patients.
  • To correlate retinal thickness with keratoconus disease severity.
  • To investigate potential retinal adaptations in response to KCN.

Main Methods:

  • Cross-sectional cohort study involving patients with KCN and healthy controls.
  • Anterior segment imaging (Pentacam HR) and posterior segment OCT (Spectralis) were performed.
  • Statistical analysis included multiple linear regression and correlation tests to assess retinal thickness and its variability relative to KCN presence and severity.

Main Results:

  • KCN patients exhibited greater posterior pole retinal thickness (superior and inferior hemifields) compared to controls.
  • A significant direct correlation was found between overall posterior pole retinal thickness and KCN severity (R² = 0.422, P < 0.001).
  • No significant difference in retinal thickness variability was observed between KCN-afflicted and healthy eyes.

Conclusions:

  • Despite KCN primarily affecting the anterior segment, an organized increase in posterior pole retinal thickness correlates with disease severity.
  • These findings suggest that the retina may exhibit plasticity, adapting to the optical aberrations caused by keratoconus.
  • Further research is warranted to explore the mechanisms of retinal adaptation in KCN.