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Updated: Dec 18, 2025

VIGS-Mediated Forward Genetics Screening for Identification of Genes Involved in Nonhost Resistance
Published on: August 23, 2013
The Ve-resistance locus, a plant signaling intercept
Ross N Nazar1, Xin Xu2, Tae Won Kim3
1Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON, N1G 2W1, Canada. rnnazar@uoguelph.ca.
Main Conclusion:
The Ve-resistance locus in tomato and potato affects both stress/defense and growth, consistent with a signaling intercept and a competitive regulatory mechanism. Acting in an antagonistic fashion, the two genes comprising the tomato Ve-resistance locus have been shown to influence both the defense/stress cascade, which causes wilt symptoms, and plant growth (Nazar et al. in Planta 247:1339-1350, 2018c); in contrast, both have been reported to elevate wilt resistance in potato or Arabidopsis. In a further examination of this influence in potato transformed with the Ve1 gene, effects are again demonstrated with respect to both disease resistance and crop productivity consistent with the Ve locus being a signaling intercept and the antagonistic effects, previously observed in tomato. The results support a competitive model in which the tomato Ve1 and Ve2 proteins act to reduce the detrimental effects of the defense/stress cascade and energy transfers to the developing potato tubers.
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